The generic name for Dolobid is diflunisal.
The medication Dolobid, which is the brand name for the generic drug diflunisal, is a nonsteroidal anti-inflammatory drug or NSAID that is used to relieve mild to moderate pain and reduce inflammation as well as swelling and stiffness that is caused by conditions like rheumatoid arthritis and osteoarthritis.
Dolobid or diflunisal treats acute or chronic mild to moderate pain, like muscle aches, sprains or dental pain and for osteoarthritis it helps to manage joint pain and stiffness from the wear and tear of joint cartilage and for rheumatoid arthritis it reduces joint swelling and inflammation caused by autoimmune attacks on the joint lining.
And sometimes dolobid or diflunisal is used off label for stabilizing transthyretin proteins to manage familial amyloidosis.
Dolobid, which is the brand name for diflunisal works by inhibiting the enzymes in the body that produce prostaglandins, which is the hormone like chemicals that trigger pain as well as fever and inflammation.
By blocking prostaglandins, diflunisal reduces swelling, joint stiffness and mild to moderate pain, which makes it particularly effective in treating musculoskeletal conditions like rheumatoid arthritis and osteoarthritis.
Unlike aspirin, which dolobid or diflunisal is structurally related to, Dolobib or diflunisal takes a couple of hours to reach it's full effect, although it often lasts significantly longer and it's often taken just every 8 hours to 12 hours.
And because of it's long half life, doctors often prescribe a higher "loading dose" like 1,000 mg of Dolobid or diflunisal right at the start of treatment, followed by smaller doses, like 250 mg to 500 mg to maintain consistent pain relief.
And like other NSAIDs, it can also cause gastrointestinal upset or even increase the risk of stomach bleeding, although it's often considered gentler on your stomach than traditional high dose of aspirin is.
Dolobid the brand name has been discontinued, although the Dolobid medication itself is still available.
While the original brand name medication under the name of Dolobid and developed by Merck is gone, the exact same active medication is still widely available under it's generic name of diflunisal.
You still also need a prescription from a doctor to get the general version of Dolobid, which is diflunisal.
Dolobid is sold under the generic name of diflunisal, in standard 250 mg and 500 mg tablets.
The brand Dolobid was not removed for safety concerns or a lack of effectiveness.
Instead the brand name of Dolobid was removed simply as a business decision to phase out the brand name version.
Diflunisal belongs to the nonsteroidal anti-inflammatory drug (NSAID) class.
And doctors mainly prescribe diflunisal for treating.
Mild to moderate pain.
Osteoarthritis.
Rheumatoid arthritis.
And diflunisal is sometimes used off label for slowing down certain conditions like certain rare diseases, like familial amyloid polyneuropathy or FAP.
Diflunisal is a nonsteroidal drug with analgesic, anti-inflammatory and antipyretic properties.
Diflunisal is a peripherally-acting non-narcotic analgesic drug.
In contrast to salicylic acid which has a plasma half- life of 2½ hours, the plasma half-life of diflunisal is 3 to 4 times longer (8 to 12 hours), because of a difluorophenyl substituent at carbon 1.
Diflunisal can cause serious bleeding, ulcers, or tears in the stomach.
These problems can occur at any time and with no warning signs.
They are more common with long-term use.