Cooking a 2lb meatloaf in the oven at 350 degrees F takes an hour to 1 hour and 25 minutes depending on how you like it.
You can put the 2lb meatloaf in the oven at 350 F degrees and cook it for 45 minutes and then after the 45 minutes you can drain some of the grease and juices off, put on the crunchy crumble topper and then put the meatloaf back in the oven and cook for another 15 minutes.
So 45 minutes and then another 15 minutes is 60 minutes that it takes to cook the meatloaf fully.
There should be no pink meat in the meatloaf when it's fully cooked but after an hour in the oven at 350 F the meatloaf should be fully cooked.
After the meatloaf is done cooking in the oven you should let the meatloaf rest for 10 minutes before cutting it and serving it.