The rarest human condition in the world is Ribose-5-Phosphate Isomerase (RPI) Deficiency.
Ribose-5-Phosphate Isomerase (RPI) Deficiency is the rarest human condition, and only a single confirmed case of Ribose-5-Phosphate Isomerase (RPI) Deficiency has been diagnosed worldwide since it was first discovered as far back as 1984.
The condition Ribose-5-Phosphate Isomerase (RPI) Deficiency is a genetic metabolic disorder that damages the white matter in your brain, which leads to seizures, psychomotor delays and muscle stiffness.
Only 1 confirmed patient in recorded history was diagnosed with Ribose-5-Phosphate Isomerase (RPI) Deficiency in 1984.
Although there could've been a few more people who have had it although it has not been confirmed.
Other rarest human conditions in the world are fields disease, fibrodysplasia ossificans progressive "Stoneman Syndrome" and NGLY1 deficiency.
Only 2 known cases of field's disease in a set of twin sisters in the UK have been confirmed worldwide.
Field's disease is a mysterious, neuromuscular condition, which causes the progressive degeneration of muscle tissue, which leaves people affected completely reliant on wheelchairs and medical support.
Fibrodysplasia Ossificans Progressiva (FOP / "Stoneman Syndrome") occurs in around 1 in 2 million people, with around 800 confirmed cases globally.
Fibrodysplasia Ossificans Progressiva (FOP / "Stoneman Syndrome") is an ultra rare genetic disorder that causes your body to repair damaged muscles, ligaments and tendons by turning them into bone.
And over time, these extra bones, lock the joints into place and severely limit your movement.
NGLY1 Deficiency affects less than 100 people worldwide.
NGLY1 Deficiency is a profound deficiency of the N-glycanase 1 enzyme.
People with NGLY1 Deficiency are unable to produce tears and have difficulty in moving certain muscles and experience severe global developmental delays.