When flying on an airplane the safest seat to be sitting in in the event of a plane crash is a middle seat in the rear.
The safest seats on an airplane are considered to be the seats farthest to the back of the airplane according to statistics.
Airplane crashes are very rare though and I've flown on probably 200 flights so far in my life and never once did we crash although at first I was very nervous.
The airline pilots are highly trained and you're likely much safer flying in an airplane with an experienced trained pilot than driving on the freeway or highway with people who don't know how to drive very good.
I take any seat on the airplane that is assigned to me and don't worry about it as even if you're on a safer seat the plane can still end up crashing and be in a very severe enough accident that everyone dies anyway.