Yes mesh office chairs with a mesh seat and mesh back are much more comfortable than regular office chairs with the padding and hard seat and hard back.
If you ever sat in an outdoor lounge chair that has mesh seating then it feels just as comfortable as that.
I find that I can sit longer in the mesh office chair than I could in my old standard office chair.
The office I worked for switched from the regular office chairs to mesh back and mesh seating office chairs and I found them much more comfortable.
I could sit longer hours and get more work done in those mesh office chairs.
So I bought a mesh office chair for my home office and love it.