Yes if you think someone may have broken into your house while you're there or you got back home and think someone has gotten into your home then yes you can and should call the police just to be safe.
It's better to call the police and not need them then not call the police and need them when someone may have broken into your house.
The police encourage people to call 911 just in case someone may be in their home so if you think someone is inside your home and should not be there then yes call the police just to be safe.
Someone could be hiding in your home and ready to harm you if you encounter them but then again it could just be something else making a sound.
But always call the police if you're unsure because that's what they are there for.