The most painful disease known to man is Trigeminal neuralgia disease.
Trigeminal neuralgia disease is also known as suicide disease.
The Suicide Disease or Fothergill's disease) is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve.
One, two, or all three branches of the nerve may be affected.
Other most painful diseases and illnesses that are known to main are.
Shingles.
Cluster headaches.
Frozen shoulder.
Broken bones.
Complex regional pain syndrome (CRPS)
Heart attack.
Slipped disc.
Sickle cell disease.