Yes Lowe's Home Improvement stores do rent trucks.
You can rent a truck from Lowe's stores to haul your items from the Lowe's stores and then bring the truck back.
For example if you have a car and need to rent a Lowe's truck to haul something such as an appliance, concrete, larger items etc then you can do so.
Just leave your vehicle there in the parking lot, rent the truck and then return the truck and get your car when you're done.
But if you need to rent a truck for longer periods such as going out of state with the truck then you should rent a U Haul Truck or Penske Truck.