Pampers Cruisers diapers are more meant for active toddlers and children and have more stretchy sides to them.
The pampers cruisers diapers hold up much better on toddlers and active children who are up and running around, climbing etc.
The pampers cruisers also sag less than pampers swaddlers do.
Both Pampers Cruisers diapers and pampers Swaddlers are good diapers though and even pampers swaddlers diapers hold up pretty good to even active toddlers and children.
The pampers swaddlers diapers are supposedly also more comfortable than Pampers cruisers according to pampers.
But unless you actually wore them yourself then there's no way to know which are more comfortable.
My kids actually preferred the Pampers Cruisers diapers and seemed more uncomfortable in the Pampers Swaddlers.
But they wore Pampers Swaddlers when they were newborn and up to a year old before I switched them to Pampers Cruisers.
Other than that there's not much difference between the two diapers of Pampers Cruisers and Pampers Swaddlers diapers.