Yes Easy Off oven cleaner is safe to use in Self Cleaning Ovens.
Just spray the Easy Off Oven Cleaner on the stains or food residue in the oven and allow it to sit for a minutes and then wipe it away.
Do not turn the self cleaning oven on though while the Easy Off is in the oven because it could potentially catch fire and create bad harmful fumes in the house.
Self Cleaning ovens do not really clean themselves but the heat helps to loosen food and grease from the oven that is spilled in it.
Then you clean the oven out yourself after the heat loosens it.
I use Easy Off in my self cleaning oven all the time to help keep it clean and it works great.