Not really. Even to heat one small room you could be looking at spending $200.00 per month to use a couple of space heaters when you could just heat the whole house with the whole house furnace.
They're okay to supplement heat or to get by if your furnace goes out. But electric space heaters are huge electric users.
They'll suck your wallet dry if it's all you use to heat your house and are not as safe to use as a whole house furnace.