The amount of gasoline your vehicle will use on 1,000 mile road trip will depend on your miles per gallon that your vehicle gets.
A vehicle will get better miles per gallon when on the highway versus just driving in town or in the city.
If your vehicle gets 15 MPG and you drive 1,000 miles then you would use around 68 gallons of gasoline to drive 1,000 miles.
If the gasoline costs $2.43 per gallon which it does right now then it would cost you $165.24 to drive 1,000 miles which is not too bad.
If your vehicle gets 25 MPG then you would use only 40 gallons of gasoline which would cost you $97.20 to drive 1,000 miles.
So the vehicle with 25 MPG would save you $68.04 which is a pretty good savings.