Yes if you take Wellbutrin or bupropion you can test positive on a drug screening test.
So if you need to take a drug test for a job or something else you should avoid taking Wellbutrin or Bupropion 24 to 48 hours before the drug screening or drug test so that you do not test positive.
If you do test positive for drugs when taking Wellbutrin or Bupropion you should show the employer your prescription for the medicine and then you still might be able to get the job.
But if possible it's better to avoid taking the medicine 24 to 48 hours before the drug test so that you don't have to worry about testing positive for drugs.
But speak with your doctor about stopping the use of the medicine temporarily just so it doesn't cause any potential health problems.