The breed of dog that has the most puppies or the largest litter of puppies is the Labrador dog breed.
The Labrador Dog Breed can have as many as 7.6 puppies in a litter which makes it the dog breed with the largest litter of puppies.
Of course the Labrador might not always have that many puppies but most times they do.
Also larger dogs have more puppies at a time than smaller dogs because the larger dog has more room for the puppies inside them.