Yes moonflowers can be dangerous to touch with your bare hands so if you need to touch the moonflowers you should wear gloves.
Touching the moonflowers could cause a skin rash or even lead to poison getting into your body through your blood stream through your skin.
Moonflowers are also very poisonous if ingested so if you have small kids and have moonflowers it's best to get rid of them.
When ingested moonflowers can lead to agitation, confusion and hallucinations and even in some cases death.