The new treatment for FAP is eRapa (encapsulated rapamycin), which has received FDA fast track designation for reducing polyps and REC-4881, which is a MEK inhibitor that shows durable reductions in polyp burden in trials.
REC-4881 MEK Inhibitor is a precision medicine that is currently in Phase 1b/2 trials, which acts on the Wnt/β-catenin signaling pathway to treat the underlying cause of FAP, showing rapid and durable reductions in polyp counts in clinical studies.
And ST316 which is a β-catenin antagonist has received FDA Orphan Drug designation to target genetic drivers of the disease.
And even Obeticholic acid is being investigated for reducing of polyps in the duodenum for people who have already undergone a colectomy.
The age that FAP also known as familial adenomatous polyposis is diagnosed is around age 16, with a range of 7 to 36 years of age and a mean diagnosis age of 34 years.
For children that have a known family history of FAP or familial adenomatous polyposis, surveillance and genetic testing often begins around ages 10 to 12.
The polyp development in FAP or familial adenomatous polyposis often begins in the teenage years, with 95 percent of people developing polyps by age 35.
The condition familial adenomatous polyposis is sometimes painful as the 100s and even 1,000s of polyps that develop can result in and cause crampy abdominal pain, diarrhea and even rectal bleeding.
Many people with familial adenomatous polyposis are usually asymptomatic initially, and the growth of the polyps in familial adenomatous polyposis often results in chronic discomfort, pain from bowel obstructions and bloating.
Abdominal pain and cramping are frequently reported in people with familial adenomatous polyposis due to the large number of polyps that are in the intestines.
The life expectancy of someone with familial adenomatous polyposis is around 42 years if they don't get treatment or get a colectomy.
Although for people that have treatment and undergo a colectomy when they have familial adenomatous polyposis, the life expectancy is often normal.
A simple blood test is how you test for familial adenomatous polyposis to see if you carry the abnormal gene which causes familial adenomatous polyposis or FAP.
The familial adenomatous polyposis condition often appears in the teenage years.
And colon polyps in familial adenomatous polyposis often develop around age 16, although can also emerge as early as age 7.
And nearly 100 percent of people develop the polyps by age 35.
Symptoms like bleeding, abdominal pain or diarrhea with familial adenomatous polyposis often follow as the polyps grow, which is often between the ages of 8 to 20 years of age.
And early screening should also occur due to high colorectal cancer risk.
The average age for the polyps to begin with familial adenomatous polyposis is age 16, but they can also range from childhood age 7 to the late teens.
And over 95 percent of people also have multiple colon polyps by age 35 years.
And by the mid teens, rectal bleeding, abdominal pain, diarrhea and changes in your stool or poop can occur.
And if untreated it carries a 100 percent risk of colorectal cancer, with an average diagnosis age of 39.
Attenuated FAP is a milder form of familial adenomatous polyposis in which polyps develop later in fewer numbers.
And cancer risk is also lower and occurs later in life than classic FAP or familial adenomatous polyposis.
FAP or familial adenomatous polyposis is an inherited condition and genetic testing can also help to identify at risk children, often beginning surveillance around age 10.
And without any intervention like colon removal, colorectal cancer is also virtually certain in familial adenomatous polyposis.