Foods that you cannot eat with Xarelto are grapefruit as well as garlic and ginger in large amounts.
Garlic and ginger can enhance the anticoagulant effects of Xarelto and raise your bleeding risk.
Grapefruit and grapefruit juice can raise the levels of Xarelto in your blood and increase your bleeding risk.
Also limit the amount of Vitamin E as high does of Vitamin E can increase bleeding risk.
And unlike when on Warfarin, you don't need to avoid vitamin K rich foods like kale, broccoli, spinach etc as these foods rich in vitamin K don't interfere with Xarelto like they do with Warfarin so you don't need to avoid them.
When taking Xarelto the 15mg and 20mg Xarelto tablets must be taken with food, and preferably with your largest meal for proper absorption.
Generic Xarelto also known as rivaroxaban (2.5 mg) is also available and can significantly reduce costs for patients with CAD and PAD.
The FDA approved the first generic of Xarelto or rivaroxaban in early 2025.
Although generics for Xarelto are not widely available yet for all doses.
And the higher doses of Xarelto like 10mg, 15mg and 20mg for DVT/PE treatment are still mostly the brand name versions and not generic yet.
The introduction of generics for Xarelto's has also led to substantial price drops.
The FDA approved the first generics for lower doses of Xarelto like 2.5 mg in early 2025 for conditions like peripheral artery disease and coronary artery disease.
The generic versions of Xarelto is also entering the market and also lowering costs significantly, but the higher doses of Xarelto are still brand name and higher in cost.
Xarelto is a prescription blood thinner also known as an anticoagulant, which reduces the risk of stroke in people with atrial fibrillation as well as treats deep vein thrombosis and pulmonary embolism and also prevents clots after having hip and knee replacement surgery.
Xarelto works by blacking the clotting protein Factor Xa.
Common side effects of Xarelto are bleeding, like nosebleeds, gastrointestinal bleeding and bruising.
As an anticoagulant, Xarelto can cause severe and potentially fatal bleeding.
And there's also a risk of blood clots in your spine if taking spinal anesthesia, which can cause long term paralysis when taking Xarelto.
You should also not stop taking Xarelto without medical supervision as it increases stroke and blood clot risk.
Xarelto can also interact with other anticoagulants, antiplatelets like aspirin, and certain strong inhibitors of CYP3A4 and P-gp, like ketoconazole or ritonavir.
Xarelto is also often taken once or twice a day, often with food.
The Xarelto tablets of 10 mg, 15 mg, and 20 mg should not be crushed, but they can be mixed with some applesauce if needed.