The organs that fail first with diabetes are the eyes, nerves, kidneys and the feet.
The eyes, nerves, kidneys and feet usually experience the earliest damage from diabetes because of their delicate blood vessels and nerves.
The eyes are frequently the first place that diabetic complications like retinopathy are noticed due to the eye's fragility and small vessels, although kidney disease, "nephropathy" and nerve damage, "neuropathy" also begin early and impact sensation and function.
Diabetes can lead to retinopathy in the eyes as tiny blood vessels in the retina get damaged by high sugar levels in the body, which result in vision problems and it's sometimes the first noticeable sign.
Damage from diabetes also often starts in the feet and the legs, and cause tingling, numbness and pain and then the hands can be affected and your sensation can also be affected.
The high blood sugar associated with diabetes, damages your kidney filters also known as nephrons and causes protein leakage and reduced function, with early changes seen in many diabetic patients.
And due to nerve damage and poor circulation with diabetes, foot ulcers and infections are also commonly early problems with diabetes.
And the larger blood vessels that supply the vital organs like your heart and brain are also harmed and increases your risk of heart attack and stroke over time.
The nerve damage with diabetes can also slow down stomach emptying and cause digestive issues.
Diabetes causes systemic damage by chronically high blood sugar harming the blood vessels and the nerves throughout your body, which makes the fragile structures like the ones in the eyes, kidneys and feet to be most vulnerable early on.