What is the life expectancy of a TUBA1A baby?

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asked 3 days ago in Baby/Newborn by sterotactic (920 points)
What is the life expectancy of a TUBA1A baby?

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answered 1 day ago by Salmorejo (46,200 points)
The life expectancy of a TUBA1A baby is around 10 years of age although some babies that are born with TUBA1A may live into their teens or even adulthood in milder cases.

Most babies born with TUBA1A don't survive or live past childhood or age 10.

And some babies born with more severe cases of TUBA1A may not even live past infancy.

TUBA1A is also related to lissencephaly which is a genetic condition that affects the brain development and causes a smooth brain surface instead of the normal folds and convolutions that a normal and healthy brain should have.

TUBA1A related lissencephaly is a condition that is part of a broader group of disorders which are called tubulinopathies and are caused by mutations in genes that are related to microtubules which are also essential components of the cell's cytoskeleton.

A major influencer in life expectancy of a TUBA1A baby is the extent of the brain malformation and severity.

Associated symptoms of TUBA1A lissencephaly include respiratory problems, developmental delays and seizures which can impact survival chances.

And even with the same genetic condition, there can also be significant variations in the severity of the symptoms of TUBA1A lissencephaly and life expectancy.

Most children with TUBA1A and lissencephaly sadly die before they reach age 10.

The common causes of death in babies and kids with TUBA1A lissencephaly are aspiration pneumonia and respiratory issues although some people that have milder forms of TUBA1A and lissencephaly may live into their teen years or adulthood years although it's less common.

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