To naturally prevent bed bugs from hiding under or on your mattress use dryer sheets under your sheets.
The bed bugs hate the scent of dryer sheets and will avoid that area.
Also using fresh or dried eucalyptus, lavender, mint, and rosemary around your house can repel bed bugs although it won't kill them.
If you have a bed bug infestation it's best to hire an exterminator who can guarantee the extermination of your bed bugs.
I paid $60.00 per room to exterminate bed bugs and they haven't come back since so it was well worth the cost.