The symptoms of Wagner syndrome are progressive night blindness, a narrowing of the field of vision, retinal detachment, nearsightedness and cataracts.
Other symptoms of Wagner syndrome are loss of movement or numbness in your fingers, toes or limbs, loss of weight and loss of appetite, vision changes, eye redness, skin rashes, joint pain, decreased hearing, malaise, fatigue, night sweats, fever, bloody noses and frequent sinusitis.
Wagner syndrome is also known as granulomatosis with polyangiitis.
Wagner syndrome is a hereditary eye disorder which causes progressive vision loss and is caused by genetic changes in the VCAN gene and is inherited in an autosomal dominant manner.
The characteristic feature of Wagner syndrome is an optically empty vitreous.
Other common findings in Wagner syndrome are myopia, vitreous veils and presenile cataract and night blindness.
Wagner syndrome is a rare condition and although the exact prevalence of Wagner syndrome is unknow, around 300 people affected have been described worldwide and about half of those people with Wagner syndrome are from the Netherlands.
Wagner syndrome was also frequently confused with Stickler syndrome although it lacks the systemic features and high incidence of retinal detachments.
If Wagner syndrome is left untreated it can lead to kidney failure and even possibly death as well as eye swelling and lung failure.
Without treatment for Wagner syndrome the average life expectancy for a person with Wagner syndrome is 5 months, with less than 50 percent of people surviving 1 year.
With treatment for Wagner syndrome, more than 80 percent of people with treated Wagner syndrome live at least 8 years and sometimes longer.