The three reasons that tablets should not be crushed are it can lead to an overdose, some tablets have protective coatings and crushing the tablets can make the medication unstable.
Crushing enteric coated tablets can also result in the drug being released too early, destroyed by stomach acid, or irritating the stomach lining.
The following medications are which cannot be crushed or broken into pieces.
ABBATIN.
Diclofenac / Misoprostol.
Rabeprazole.
Cyclobenzaprine.
Aspirin.
Acxion ap.
Akineton delayed
Estradiol/drospirenone.
Angiotrofin delayed.
Farma Leal ASOFLON LP 0.4 mg 30 Caps.
Atemperator.
Hazardous medications.
Modified release medicines.
Not crushing the medicines is of particular importance with hormonal, cytotoxic or steroidal medications.
If the tablet is crushed, the drug may go into the air and the dose inadvertently be received by the administrating nurse or carer.
Crushing extended-release meds can result in administration of a large dose all at once.
Crushing delayed-release meds can alter the mechanism designed to protect the drug from gastric acids or prevent gastric mucosal irritation.
Crushing sublingual or buccal tabs can alter effectiveness.
Medications may be inappropriate to crush if they have enteric or slow-release coatings; are sublingual or buccal formulations; have the potential to irritate the skin or mouth when crushed; have antineoplastic, cytotoxic, or teratogenic properties; or have a potentially unacceptable taste.
Crushing enteric coated tablets may result in the drug being released too early, destroyed by stomach acid, or irritating the stomach lining.
In general, manipulation of enteric coated and extended-release formulations is not, therefore, recommended.