Kratom can cause a low heart rate or slowed heart rate also known as bradycardia and even cardiac arrest.
The receptors that kratom binds to are the supraspinal mu- and delta- opioid receptors.
Kratom can also cause hot flashes in some people as well as loss of libido, heartburn, dehydration, nausea, seizures, dry mouth, loss of appetite, constipation,itching and skin rashes.
People who take or use kratom have also experienced weight loss, anorexia, hepatotoxicity, seizures, insomnia and hallucinations.
The side effects from taking kratom include aggression, nausea, trouble breathing, hallucinations and even death.
Kratom can be unsafe for most people when taken by mouth and large doses of kratom can cause serious side effects.
The positive effects of Kratom are improved mental health, relief of pain, increased energy levels, feelings of pleasure and or euphoria, reduced anxiety and feeling more relaxed.
The active ingredient in kratom is mitragynine which is an indole-based alkaloid and the most abundant active alkaloid in the Southeast Asian plant Mitragyna speciosa.
Kratom also known as mitragyna speciosa is a tropical evergreen tree in the coffee family native to Southeast Asia.
It is indigenous to Cambodia, Thailand, Indonesia, Malaysia, Myanmar, and Papua New Guinea, where it has been used in herbal medicine since at least the 19th century.
Potential kratom health benefits include increased energy, euphoria, and pain relief.
In one 2016 study of 8,000 kratom users, individuals self-reported an improvement in acute and chronic pain and mood disorders like anxiety and depression.
While some research suggests that kratom may help relieve some of the symptoms of depression, scientists are not yet sure that it is effective.
It also carries some severe risks that a person should be aware of before using it.
Kratom is an herbal extract from an evergreen tree called Mitragyna speciosa.
While kratom is most commonly known for its affinity to opioid receptors, it also has affinity to serotonin and dopamine receptors, signaling its potential for treating depression, anxiety, and psychosis.