The drug samidorphan does sometimes make you tired or drowsy and may even cause somnolence, dry mouth, headache and anxiety.
Samidorphan does help you lose weight and decreases weight gain as well as reduces insulin resistance, triglyceride levels and blood pressure which also helps in reducing your risk of cardiovascular problems.
The reason samidorphan prevents weight gain is by binding to mu-opioid, kappa-opioid, and delta opioid receptors which is hypothesized to reduce your cravings for high calorie foods which prevents antipsychotic induced weight gain.
You can combat weight gain from olanzapine by taking samidorphan which is given with olanzapine to reduce weight gain.
The reason why you add samidorphan to olanzapine is to reduce weight gain in people taking olanzapine for schizophrenia.
Some people gain weight when taking olanzapine alone so the sanidorphan is given with olanzapine to prevent the weight gain.
Samidorphan is a schedule II controlled substance because it can be derived from opium alkaloids.
Samidorphan is not an opioid but instead Samidorphan is an Opioid antagonist.
The Opioid antagonists are medications which block opioids effects.
Opioid antagonists also help treat opioid overdose, opioid use disorder, alcohol use disorder and opioid-induced constipation.
Samidorphan is a schedule II controlled substance because it can be derived from opium alkaloids.
Samidorphan reduces the risk of weight gain caused by olanzapine.
There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure.
The drug samidorphan has been observed to produce some side effects that are potentially consistent with activation of the KOR such as somnolence, sedation, dizziness, and hallucinations in some patients in clinical trials.
Samidorphan is a novel naltrexone analogue containing a 3-carboxamido group that functions as an opioid receptor modulator, both in vitro and in vivo.
Samidorphan is a novel opioid antagonist that binds to mu-opioid, kappa-opioid, and delta-opioid receptors and is hypothesized to reduce cravings for high-calorie foods thus attenuating antipsychotic-induced weight gain.
Lybalvi (olanzapine/samidorphan) is a member of the psychotherapeutic combinations drug class and is commonly used for Bipolar Disorder, and Schizophrenia.
The cost for Lybalvi (10 mg-10 mg) oral tablet is around $1,693.00 for a supply of 30 tablets, depending on the pharmacy you visit.
Olanzapine and samidorphan combination is used to treat schizophrenia.
It may also be used alone or with other medicines (eg, lithium or valproate) to treat mania or mixed episodes that is part of bipolar disorder (manic-depressive illness).