CD30 Positive means that a cell surface marker that is called CD30 which is a protein receptor is present on the surface of certain cells and most particularly those cells involved in Hodgkin Lymphoma and certain types of non Hodgkin Lymphoma.
CD30 is also known as TNFRSF8 "tumor necrosis factor receptor superfamily member 8", which is a protein receptor that is found on the surface of specific cells, which include certain immune cells and cancer cells.
CD30 tumor markers are important and means that it's presence or level can indicate the prescence or activity of certain cancers and most particularly lymphomas.
The lymphomas which are CD30 positive are Hodgkin Lymphoma, Anaplastic Large cell Lymphoma and other lymphomas.
CD30 is expressed on Hodgkin and Reed Sternberg cells, which are characteristic of Hodgkin lymphoma.
CD30 is also a hallmark marker of ALCL, which is a type of non Hodgkin lymphoma.
And CD30 can also be expressed in other types of non Hodgkin lymphoma which includes primary mediastinal large B cell lymphoma "PMBCL" and some cases of cutaneous T cell lymphoma.
The presence of CD30 on lymphoma cells can help to diagnose the types of lymphoma.
CD30 can also be a target for therapies as some treatments such as brentuximab vedotin, specifically target CD30 positive cells.
CD30 expression is also seen in some non neoplastic skin disorders such as lymphomatoid papulosis.