The revision of detail but not of basic principle that the hypothesis has undergone as more information was gained is one gene- one polypeptide hypothesis.
Scientists discovered that all proteins are also enzymes and a single gene can code for a single polypeptide change within a protein complex.
One gene - one enzyme suggest that each gene directly codes for a single enzyme protein.
And with further research, scientists have also found that many proteins are also composed of multiple polypeptide changes and each are encoded by a separate gene.
This also led to the revised one gene one polypeptide hypothesis and is more accurately what reflects the relationship between proteins and genes.
While the basic principle of a gene controlling a specific protein function remained the same, the detail of the protein being a single polypeptide change rather than a whole enzyme was also refined with new information.
The revision of detail in a hypothesis occurs as scientists gather more information through experimentation and research.
As more information was gained, the one gene - one enzyme hypothesis was restated as the one gene - one polypeptide (protein) hypothesis.