Does L tyrosine cross the blood brain barrier?

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asked May 2, 2022 in Other- Health by JorelFlorke (8,300 points)
Does L tyrosine cross the blood brain barrier?

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answered May 2, 2022 by Cathy21 (86,370 points)
L Tyrosine does cross the blood brain barrier.

Acidic amino acids Glu and Asp are transported from brain to blood; at the abluminal membrane this efflux is mediated by excitatory amino acid transporters (EAAT), encoded by genes from an SLC1 family.

Tyrosine readily crosses the blood-brain barrier and is the starting point for producing L-DOPA dopamine epinephrine and norepinephrine.

Tyrosine and L Tyrosine are essentially the same thing.

L-tyrosine is actually one form of the amino acid tyrosine and it is a non-essential amino acid, meaning that you don't have to get it from food.

And the body manufactures it, using another amino acid, phenylalanine.

You may see tyrosine sold in supplement form with or without the "L."

Foods that contain L Tyrosine include soy products, chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, and sesame seeds.

L Tyrosine makes you feel happy, improves your mood, reduces stress and also improves your memory.

Tyrosine supplements can cause insomnia, restlessness, palpitations, headache, upset stomach, and heartburn.

L Tyrosine is good for depression.

Two clinical studies on depressed patients and healthy volunteers have shown that treatment with L-tyrosine has a positive role in depression management, mediated by NA and dopamine levels.

L Tyrosine does help to lower blood pressure.

People who have had the L Tyrosine injection have noticed lowered blood pressure from the L Tyrosine.

Taking extra tyrosine might increase thyroxine levels too much.

This could make hyperthyroidism and Grave's disease worse. If you have a thyroid disorder, don't take tyrosine supplements.

The benefits of L Tyrosine are helping your body build proteins, produce enzymes, skin pigment melanin and increases and improves thyroid hormones.

Another benefit of L Tyrosine is it also helps the body produce neurotransmitters that help nerve cells communicate.

Tyrosine is particularly important in the production of epinephrine, norepinephrine, and dopamine.

The side effects of L Tyrosine include nausea, heartburn, headache, joint pain, fatigue and feeling tired.

L Tyrosine is generally safe to take in the recommended dosages and under the direction of a doctor on the dosage amount for you.

However L Tyrosine can interact with some medicines including some medications taken for thyroid problems or depression, and with levodopa, taken for Parkinson's disease.

L Tyrosine may be safe during pregnancy but you should avoid taking L Tyrosine or Tyrosine when pregnant or breastfeeding as it could possibly harm the unborn baby or complicate pregnancy.

Also the L Tyrosine could get into the breast milk and harm the baby when they feed on the breast milk.

You start to wonder whether taking amino acid supplements might be a good way to make sure that your baby gets the nutrients they need.

In fact, amino acid supplements are not recommended during pregnancy.

L Tyrosine does help with weight loss as the L Tyrosine helps to speed up the bodies metabolism which aids in weight loss.

Tyrosine is in all tissues of the human body and in most of its fluids.

It helps the body build proteins in your body, and produce enzymes, thyroid hormones, and the skin pigment melanin.

It also helps the body produce neurotransmitters that help nerve cells communicate.

Although L Tyrosine can help your body naturally tan better but it's not a result of the L Tyrosine directly that causes you to tan.

Other nutrients can help the skin by assisting in the production of melanin - the pigment that darkens the skin during tanning and acts as a natural sunscreen.

Melanin is made from an amino acid known as L-tyrosine, and taking 1,000-1,500mg of this each day as a supplement can help the body tan quite naturally.

For thyroid the L Tyrosine increases the bodies thyroxine levels.

The body uses tyrosine to make thyroxine, a thyroid hormone so by increasing the thyroxine levels it helps the thyroid.

Since tyrosine is involved in the production of thyroid hormones, you should not use L-tyrosine if you have a thyroid condition such as hyperthyroidism or Graves disease.

It could cause your levels to go too high. Some tyrosine is converted into the neurotransmitter epinephrine.

Tyrosine is not a stimulant itself but Tyrosine does work in conjunction with other stimulants such as methylphenidate (i.e. Ritalin).

Tyrosine can also help some people stay mentally sharp when you have lost sleep.

In one study, subjects were kept awake for over 24 hours.

Those who took tyrosine performed much better on two types of tasks than those who took a placebo.

The effect lasted around three hours.

Foods that are high in tyrosine include beef, pork, fish, chicken, tofu, milk, cheese, beans, seeds, nuts, and whole grains.

The reference dietary intake (RDI) of phenylalanine and tyrosine is 25mg per kilogram of body weight or 11mg per pound.

Tyrosine is found in soy products, chicken, turkey, fish, peanuts, almonds, avocados, bananas, milk, cheese, yogurt, cottage cheese, lima beans, pumpkin seeds, and sesame seeds.

Aromatic amino acids are actually relatively non polar.

Tyrosine's phenolic side chain has a hydroxyl substituent and tryptophan has a nitrogen atom in its indole ring sytem.

These residues are nearly always found to be largely buried in the hydrophobic interior of a proteins as they are prdeominantly non-polar in nature.

D phenylalanine is a type of amino acid.

The D-Phenylalanine is a synthetic dextro isomer of the phenylalanine which is an essential amino acid with anti-depressant and analgesic activities.

Also D-Phenylalanine is converted into tyrosine and tyrosine in turn is converted into L-dopa, norepinephrine, and epinephrine, three key neurotransmitters.

Phenylalanine is involved in the production of the neurotransmitters norepinephrine and dopamine, which are essential for the proper functioning of the brain and nervous system.

Phenylalanine also helps with the production of the pigment melanin, which gives color to the skin, hair, and eyes.

Phenylalanine is thought to mediate or exacerbate hepatic encephalopathy, and an impaired liver may not be able to cope with the ammoniagenic properties of the amino acid constituents, or adequately metabolize methanol.

Phenylalanine can cause intellectual disabilities, brain damage, seizures and other problems in people with PKU.

Phenylalanine occurs naturally in many protein-rich foods, such as milk, eggs and meat.

Phenylalanine is also sold as a dietary supplement.

A musty odor in the breath, skin or urine, caused by too much phenylalanine in the body.

Neurological problems that may include seizures.

Skin rashes (eczema) Fair skin and blue eyes, because phenylalanine can't transform into melanin — the pigment responsible for hair and skin tone.

The researchers found that the single-dose of phenylalanine reduced food intake, increased levels of GLP-1 and decreased levels of ghrelin.

Repeated administration also caused weight loss in the obese mice.

For best results, phenylalanine should be taken between meals, because the protein present in food can interfere with the uptake of phenylalanine into the brain, potentially reducing its effect.

D- and DL-phenylalanine are typically taken at a dose of 100 to 200 mg daily for the treatment of depression.

For the treatment of chronic pain, studies have used D-phenylalanine in doses as high as 2,500 mg daily.

High blood levels of phenylalanine can saturate the transport system across the blood-brain barrier and cause inhibition of the cerebral uptake of other large neutral amino acids such as branched-chain amino acids, tyrosine, and tryptophan, impairing brain protein synthesis.

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