Why intraperitoneal route is not used clinically?

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asked Aug 8, 2023 in Other- Health by Ironside (1,460 points)
Why intraperitoneal route is not used clinically?

2 Answers

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answered Aug 18, 2023 by Zoey123 (24,130 points)
The reason intraperitoneal route is not used clinically is because they can have a large variability in misinjection and effectiveness.

The intraperitoneal injections can be similar to oral administration in which hepatic metabolism can occur in both.

The safest place to do an intraperitoneal injection is in the cavity in the lower abdominal quadrant.

The intraperitoneal injection should be made in the lower (caudal) left quadrant of the abdomen, to avoid the more cranially located organs such as the liver, and the cecum, which tends to be on the right.

The intraperitoneal organs are located in the peritoneal cavity which contains the mesentery, ligaments and omentum.

The intraperitoneal organs are the sigmoid colon, transverse, ileum, jejunum, first and fourth parts of the duodenum, liver, spleen and the stomach.

Intraperitoneal organs are the organs having a mesentery, such as the stomach, small intestine (jejunum and ileum), transverse colon, liver and gallbladder.

The difference between peritoneal and retroperitoneal is.

Intraperitoneal: peritonealized organs having a mesentery, such as the stomach, small intestine (jejunum and ileum), transverse colon, liver and gallbladder.

Retroperitoneal: organs without a mesentery and associated with posterior body wall, such as the aorta, inferior vena cava, kidneys and suprarenal glands.

The kidneys are called retroperitoneal because the kidneys sit behind a lining in your abdominal cavity, unlike all the other abdominal cavities.

The pancreas is called a retroperitoneal organ because it has no specific delineating anatomical structures and they have peritoneum on their anterior side only.

The human pancreas plays a big role in digestion and is located inside the abdomen, just behind the stomach.

Your pancreas is about the size of your hand.

During digestion, the pancreas makes pancreatic juices called enzymes.

These enzymes break down sugars, fats, and starches.

If you have a cancerous tumor on your pancreas you will usually live for around a year after diagnoses without treatment.

With treatment you may live for up to 5 years with the cancerous pancreas tumor.

Not all tumors on the pancreas are cancer so you may live a long life with the non cancerous tumor but the cancerous tumor can be and is deadly.

You can survive a pancreatic tumor if the tumor is caught soon enough and treated.

However without treatment you will die much sooner from the pancreatic tumor if it's cancerous and even with treatment you can still survive but not for too long.

You can remove a tumor from the pancreas through surgery and the whipple procedure.

Sometimes if a pancreatic NET is small, just the tumor itself is removed.

This is called enucleation. This operation may be done using a laparoscope, so that only a few small cuts on the belly are needed.

This operation may be all that is needed to treat an insulinoma.

A tumor on the pancreas can be either serious and cancerous or not serious and non cancerous.

Not all tumors on the pancreas turn out to be cancer and some tumors on the pancreas are harmless but even so you should get checked out.

If the tumor on your pancreas is cancerous then it's serious as it can be fatal if not removed or treated.

Chemo is worth it for pancreatic cancer if the pancreatic cancer has not progressed too far and you want to increase your life expectancy and live a bit longer.

Having chemo for pancreatic cancer can increase your lifespan so it can be worth it unless you're older and don't see it as worth it.

While chemotherapy may not cure cancer, it along with radiation therapy may improve the chances of survival and result in an improved quality of life.

Pancreatic cancer can go from Stage 1 to Stage 4 in a year although it may take a few years as it can vary.

After the first cancer cell appears, it takes an average of nearly seven years for that cell to turn into the billions that make up a cancerous tumor the size of a plum, after which at least one of the cells within the tumor has the potential and ability to spread to other organs.

Tumors in the pancreas are not always cancerous.

However if you think you have a tumor on your pancreas it should be checked out to be sure it's not cancerous and it's best to have the pancreas tumor removed even when it's not cancer.

A CT scan can show pancreatic cancer as the CT scan can get a clear picture of the pancreas making it pretty easy to detect pancreatic cancer.

The first symptom of pancreatic cancer is usually Jaundice and yellowing of the eyes.

Abdominal pain is also another common first symptom of pancreatic cancer.

The 5 signs of pancreatic cancer include.

Jaundice.

Back Pain.

Abdominal Pain.

Bloating.

Nausea and even Vomiting.

Pancreatic cancer has a survival rate of 5 years.

Some people may live longer or shorter depending on how far progressed the pancreatic cancer is.

Compared to other cancers, pancreatic cancer is relatively rare.

But it is the third leading cause of cancer death in the United States.

Only about 8.5% of patients with pancreatic cancer are alive five years after their diagnosis.

This one of the lowest survival rates for any kind of cancer.

In some cases it is possible to have pancreatic cancer for years without knowing as it can be slow growing and not show any signs or symptoms for awhile.

Pancreatic cancer is cancer that begins in the organ lying behind the lower part of the stomach (pancreas).

The pancreas secretes enzymes that aid digestion and hormones that help regulate the metabolism of sugars. This type of cancer is often detected late, spreads rapidly, and has a poor prognosis.

There are no symptoms of pancreatic cancer in the early stages.

Later stages of pancreatic cancer are associated with symptoms, but these can be non-specific, such as lack of appetite and weight loss.

Treatment for pancreatic cancer may include surgically removing the pancreas, radiation, and chemotherapy.

Some early warning signs of pancreatic cancer are Jaundice which is yellowing of the skin, sudden unexplained weight loss, poor appetite, Vomiting, Nausea, Gallbladder Enlargement, Liver Enlargement, Blood Clots and even Diabetes.

Other Symptoms of Pancreatic Cancer are Abdominal Pain, Middle Back Pain, Fatigue and even yellowing of the eyes.

DNA is thought to be the #1 cause of pancreatic cancer.

Most people who get pancreatic cancer get the pancreatic cancer through mutations and DNA.

However sometimes not eating healthy or being overweight can lead to pancreatic cancer but the actual cause of pancreatic cancer is not 100 percent known for sure.

The average length of time a person has to live after being diagnosed with pancreatic cancer is 3 to 6 months.

However there have been some people who have lived 1 year to 2 years and in some cases up to 3 years after being diagnosed with pancreatic cancer.

If you do get treatment for the pancreatic cancer and have surgery to remove the pancreatic cancer then you can usually survive longer.

However pancreatic cancer can sometimes come back.

If the pancreatic cancer has not progressed too far then sometimes the pancreatic cancer can be cured.

However if the pancreatic cancer has not been caught soon enough and treatment has not started soon enough for the pancreatic cancer then it has a lower chance of being cured.

The way pancreatic cancer is cured is through surgery and the surgeon cuts into your pancreas and removes the cancer.

However the longer you wait the further progressed the pancreatic cancer becomes and when it gets too bad then it cannot usually be cured.

There's a lot of people that have survived pancreatic cancer since they got the pancreatic cancer diagnosed and removed soon enough.

However the older you are the less chance of survival you have if you have pancreatic cancer.
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answered Aug 18, 2023 by UnderPleas (510 points)

The intraperitoneal route refers to the administration of drugs or fluids directly into the peritoneal cavity, which is the space within the abdominal cavity that surrounds the abdominal organs. While this route can be used for certain medical procedures and treatments, it is not commonly used clinically for several reasons:

  1. Risk of Infection and Peritonitis: The peritoneal cavity is a sterile environment, and introducing foreign substances through the intraperitoneal route can increase the risk of infection and peritonitis, which is inflammation of the peritoneum. This can be a serious complication that requires medical intervention.

  2. Limited Absorption: The peritoneal membrane is not as efficient at absorbing substances as other routes, such as intravenous administration. This can result in slower and less predictable absorption of drugs or fluids, making it less suitable for time-sensitive treatments.

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