The Karo and regular corn syrup are similar in a way but Karo Syrup is a light corn syrup where as Corn Syrup is a thicker corn syrup then Karo syrup.
Also Karo corn syrup is made with Vanilla that's real and corn syrup is made with refiners syrup which is essentially molasses.
Corn Syrup has a more robust flavor and color and is preferred for many, many more baked goods.